CURB THE LINE
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WHAT is Curb the Line?

Curb the Line is a research study being conducted by the San Francisco Department of Public Health. We are testing the effectiveness of a medication in individuals who use cocaine, including powder and/or crack. The goal of this study is to see if this medication helps to reduce cocaine use.

STUDY INFORMATION

WHY ARE MEDICATIONS BEING GIVEN TO COCAINE USERS?

We ultimately want to learn whether a medication called Lorcaserin can help people to reduce their cocaine use and negative consequences that come along with cocaine use such as high-risk behaviors. 

STUDY PARTICIPATION

If you are eligible and choose to enroll in the study, you will be randomized to the medication, Lorcaserin or placebo which you will taken daily for 12 weeks. During that time you would come in every week for counseling, questionnaires and clinical exams. You will be paid for every visit. You will also receive brief, daily text messages asking you if you took your medication. You will be paid each day you respond to these text messages. You can earn up to $439 for participating in this study.

AM I ELIGIBLE?

Call us at 415-437-6314 or send us your contact information using the contact form on this page to see if you might qualify. If you do, we will set up the first screening visit for you to come in to our office to see if you meet further study criteria. Determining study eligibility involves meeting with a counselor and clinical staff, answering questions on your physical and mental health, having a physical exam, and giving a urine sample. 


Please note, this study is open for individuals regardless of HIV status. 

HOW MAY TAKING A MEDICATION HELP TO REDUCE POWDERED AND/OR CRACK COCAINE-USE?

Laboratory and in-patient clinic studies suggest that Lorcaserin may activate parts of the brain that will help reduce the effects of cocaine or crack. However, it is important to understand that we do not yet know if this medication will lead to reductions in cocaine or crack use.

Additionally, because this study is double-blind and randomized, you would receive either the medication or placebo; all participants will receive weekly harm-reduction counseling.

HOW WILL I KNOW IF I RECEIVED THE DRUG?

Neither you nor the study staff will know if you are receiving the medication or placebo (both the medication and placebo look exactly the same). You will be monitored for any reactions you may have to the study drug and the study clinician will be readily available to discuss any issues you may have. After the study has been fully enrolled and completed, we will contact each participant and inform you if you received the medication or the placebo.  

WHAT IF I DECIDE TO DROP OUT OF THE STUDY AFTER ENROLLING?

As a study participant, you are free to end your participation at any time. Study staff will work with you to accommodate any difficulties you have in making study visits. 

Contact Us

If you are interested in participating or to get more information, please complete the form below.

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CURB THE LINE

25 Van Ness Ave, Suite 500, San Francisco, CA 94102, US

(415) 437-6314