Curb the Line is a research study being conducted by the San Francisco Department of Public Health. We are testing the effectiveness of a medication in individuals who use cocaine, including powder and/or crack. The goal of this study is to see if this medication helps to reduce cocaine use.
We ultimately want to learn whether a medication called Lorcaserin can help people to reduce their cocaine use and negative consequences that come along with cocaine use such as high-risk behaviors.
If you are eligible and choose to enroll in the study, you will be randomized to the medication, Lorcaserin or placebo which you will taken daily for 12 weeks. During that time you would come in every week for counseling, questionnaires and clinical exams. You will be paid for every visit. You will also receive brief, daily text messages asking you if you took your medication. You will be paid each day you respond to these text messages. You can earn up to $439 for participating in this study.
Call us at 415-437-6314 or send us your contact information using the contact form on this page to see if you might qualify. If you do, we will set up the first screening visit for you to come in to our office to see if you meet further study criteria. Determining study eligibility involves meeting with a counselor and clinical staff, answering questions on your physical and mental health, having a physical exam, and giving a urine sample.
Please note, this study is open for individuals regardless of HIV status.
Laboratory and in-patient clinic studies suggest that Lorcaserin may activate parts of the brain that will help reduce the effects of cocaine or crack. However, it is important to understand that we do not yet know if this medication will lead to reductions in cocaine or crack use.
Additionally, because this study is double-blind and randomized, you would receive either the medication or placebo; all participants will receive weekly harm-reduction counseling.
Neither you nor the study staff will know if you are receiving the medication or placebo (both the medication and placebo look exactly the same). You will be monitored for any reactions you may have to the study drug and the study clinician will be readily available to discuss any issues you may have. After the study has been fully enrolled and completed, we will contact each participant and inform you if you received the medication or the placebo.
As a study participant, you are free to end your participation at any time. Study staff will work with you to accommodate any difficulties you have in making study visits.